Lymphoma- Types, Diagnosis and Treatment

Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network. The lymphatic system includes the lymph nodes (lymph glands), spleen, thymus gland and bone marrow. Lymphoma can affect all those areas as well as other organs throughout the body.

Types

• Chronic lymphocytic leukemia
• Cutaneous B-cell lymphoma
• Cutaneous T-cell lymphoma
• Hodgkin's lymphoma (Hodgkin's disease)
• Non-Hodgkin's lymphoma
• Waldenstrom macroglobulinemia

Symptoms

Signs and symptoms of lymphoma may include:

• Painless swelling of lymph nodes in your neck, armpits or groin
• Persistent fatigue
• Fever
• Night sweats
• Shortness of breath
• Unexplained weight loss
• Itchy skin

Causes

Doctors aren't sure what causes lymphoma. But it begins when a disease-fighting white blood cell called a lymphocyte develops a genetic mutation. The mutation tells the cell to multiply rapidly, causing many diseased lymphocytes that continue multiplying.

The mutation also allows the cells to go on living when other normal cells would die. This causes too many diseased and ineffective lymphocytes in your lymph nodes and causes the lymph nodes, spleen and liver to swell.

Diagnosis

• Physical exam. Your doctor checks for swollen lymph nodes, including in your neck, underarm and groin, as well as a swollen spleen or liver.
• Removing a lymph node for testing. Your doctor may recommend a lymph node biopsy procedure to remove all or part of a lymph node for laboratory testing.
• Blood tests. Blood tests to count the number of cells in a sample of your blood can give your doctor clues about your diagnosis.
• Removing a sample of bone marrow for testing. A bone marrow aspiration and biopsy procedure involves inserting a needle into your hipbone to remove a sample of bone marrow. The sample is analyzed to look for lymphoma cells.
• Imaging tests. Your doctor may recommend imaging tests to look for signs of lymphoma in other areas of your body. Tests may include CT, MRI and positron emission tomography (PET).

Treatment

Which lymphoma treatments are right for you depends on the type and stage of your disease, your overall health, and your preferences. The goal of treatment is to destroy as many cancer cells as possible and bring the disease into remission. Lymphoma treatments include:

• Active surveillance. 
• Chemotherapy
• Radiation therapy. 
• Bone marrow transplant.
• Other treatments.

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