Changes in Thyroid Stimulating Antibody Levels in Graves’ Disease Patients

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Radioactive iodine therapy (RAIT) is a useful option in the treatment of Graves’ disease; other treatment options include antithyroid drugs (ATDs) and surgery. Endocrinologists select appropriate therapies based on clinical characteristics such as age, thyroid volume, complications, and whether the patient is planning to become pregnant.  RAIT does not require hospitalization and can reliably correct hyperthyroidism; however, changes in thyrotropin receptor antibody (TRAb) and thyroid stimulating antibody (TSAb) levels significantly influence the course of pregnancy and the development or exacerbation of Graves' ophthalmopathy.

In a study by Laurberg et al. patients with Graves' disease were randomly assigned to ATD treatment, thyroidectomy, or RAIT group, and their clinical courses were reviewed prospectively. In the ATD and thyroidectomy groups, TRAb levels decreased gradually after treatment, and 70-80% of patients were observed to be TRAbnegative at 18 months; however, in the RAIT group, TRAb levels increased after treatment, reached a maximum at three months, and then decreased gradually to pre-treatment levels one year post-treatment. Laurberg et al. found that there were fewer TRAb negative patients in the RAIT group than in the other groups.

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Denise Williams
Editorial Manager     
Journal of Thyroid Disorders & Therapy
E-mail id: Thyroiddisorders@emedscholar.com